Musk xylene is a kind of artificial musk, chemicals name is 2,4, 6-trinitro -5-tert-butyl m-xylene. Pale yellow needle-like crystals with a strong musky air. The molecular formula is C12H15N3O6, the molecular weight is 297.27, and the melting point is 112.5-114.5 ℃. Boiling point 200-202 ℃. Poor solubility in ethanol, soluble in diethyl phthalate. It is explosive.

Product use: Used as a fixative for cosmetic flavors and soap flavors. Musk xylene is also used as a transdermal agent in many Chinese ointment patches, increasing the epidermal absorption of drugs, and has sedative and analgesic effects. Although this product is called artificial musk, it is a single compound, which is different from musk. It is a natural multi-component mixture. The drug made of musk contains pranandrosterone, which is classified as a stimulant and has certain restrictions on its use, while xylene musk, which avoids this restriction, has been paid attention to by some people in the industry.

Common Process Routes

The m-xylene and tert-butyl chloride generate tert-butyl xylene solution under the action of anhydrous aluminum trichloride, the oil phase is separated, and the precipitated oil phase is washed with dilute hydrochloric acid, soda ash solution and distilled water until neutral. Vacuum distillation, tert-butyl xylene. Fuming nitric acid and concentrated sulfuric acid were added to t-butylxylene. The nitration reaction was carried out, and after the reaction, the crude xylene musk product was obtained by water washing, separation, neutralization and filtration. The crude product was purified by recrystallization to obtain pure needle-like crystals of xylene musk, which was pale yellow and had a soft musk odor.

Market development trend analysis

For a long time, musk mainly comes from wild forest musk deer, but due to the high economic value of musk, the situation of indiscriminate forest musk deer is becoming more and more serious, and the number of forest musk deer in China has dropped to less than 50000. As a result, natural musk quotas are strictly controlled by the state and production capacity is severely limited. There are many technical difficulties in forest musk deer breeding, and it is difficult to expand on a large scale in a short time. Musk has been in short supply for many years, which provides a good opportunity for the development of artificial musk.

Artificial musk as a Chinese patent medicine raw materials to benefit many pharmaceutical enterprises, to alleviate the long-term musk since the founding of the situation can not meet the demand. From 1994 to 2017, a total of 140 tons of artificial musk was put on the market, which is equivalent to protecting 40 million heads of wild musk deer resources in my country. It completely changed the traditional way of "killing musk deer and getting incense", and contributed to the restoration of musk deer resources and the sustainability of the ecological environment in my country. Development has made great contributions. The cumulative sales of artificial musk reached 8 billion yuan. Pay 1.8 billion yuan in profits and taxes; Every year, it drives relevant traditional Chinese medicine enterprises to exceed 30 billion yuan in industrial added value, making a significant contribution to the profits and taxes of local governments.

After the advent of artificial musk, it has produced huge social, economic and ecological benefits. Statistics show that at present, a total of 760 enterprises in China produce and sell 433 kinds of Chinese patent medicines containing musk, of which 431 kinds completely replace natural musk with artificial musk, and the replacement rate of artificial musk reaches more than 99%. Since 2018, the price trend of China's artificial musk market has been relatively stable. At the beginning of 2018, the price of artificial musk was 20000 yuan/kg, and it has been stable at 50000 yuan/kg from 2019 to 2020.